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Catalogue
Number
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Product
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Order number / Unit
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2070
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GR89696 fumarate
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2070.0001: 1 mg per vial
2070.0005: 5 mg per vial
2070.0010: 10 mg per vial
Please inquire for customized
filling and bulk quantities.
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Reference standard for (R)-(-)-[11C]GR103545
and (S)-(+)-[11C]GR103545
Highly potent and selective κ opioid receptor agonist
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Molar Mass: 530.40
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C19H25Cl2N3O3 ⋅ C4H4O4
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[126766-32-3]
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Off-white solid packaged in dark glass crimp cap vials.
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Purity: > 95 %
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Certificates:
CoA; 1H NMR and 13 NMR spectra
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Chemical Name:
CA index name: 1-Piperazinecarboxylic acid, 4-[(3,4-dichlorphenyl)acetyl]-3-(1-pyrrolidinylmethyl)-, methyl ester, (E)-2-butenedioate (1:1)
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Synonymes:
GR89696 fumarate salt; 4-[(3,4-dichlorphenyl)acetyl]-3-(1-pyrrolidinylmethyl)-1-piperazinecarboxylic acid methyl ester fumarate
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Literature:
1. Ravert H.T. et al. [11C]-GR89696, a potent kappa opiate receptor radioligand; in vivo binding of the R and S enantiomers. Nuc. Med. Biol. 2002, 29, 47-53.
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2. Talbot P.S. et al. 11C-GR103545, a Radiotracer for Imaging κ-Opioid Receptors In Vivo with PET: Synthesis and Evaluation in Baboons. J. Nucl. Med. 2005, 46, 484-494.
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3. Naylor A. et al. A Potent New class of κ-Receptor Agonist: 4-Substituted 1-(Arylacetyl)-2-[(dialkylamino)methyl]piperazines. J. Med. Chem. 1993, 36, 2075-2083.
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4. Schoultz B.W. et al. A New Method for Radiosynthesis of 11C-Labeled Carbamate Groups and its Application for a Highly Efficient Synthesis of the Kappa-Opioid Receptor Tracer [11C]GR103545. The Open Med. Chem. J. 2008, 2 ,72-74.
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date of product catalogue issue:
05 April 2012
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