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Catalogue
Number
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Product
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Order number / Unit
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2872
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5-Methyl-2,4-bis[(trimethylsilyl)oxy]pyrimidine
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2872.0100: 100 mg per vial
Please inquire for customized
filling and bulk quantities.
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Precursor 2 for [18F]FMAU
(2′-deoxy-2′-[18F]fluoro-5-methyl-1-β-D-arabinofuranosyluracil)
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Caution, very sensitive to moisture!
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Molar Mass: 270.48
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C11H22N2O2Si2
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[7288-28-0]
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Colourless solid packaged in dark glass crimp cap vials.
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Purity: > 95 %
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Certificates:
CoA; 1H and 13C NMR spectra
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Chemical Name:
CA index name: Pyrimidine, 5-methyl-2,4-bis[(trimethylsilyl)oxy]-
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Synonymes:
2,4-Bis(trimethylsiloxy)-5-methylpyrimidine; 2,4-Bis(trimethylsilyl)-5-methyluracil; 2,4-Bis-O-(trimethylsilyl)thymine; O,O′-Bis(trimethylsilyl)thymine; Bis(O-trimethylsilyl)thymine
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Literature:
1. Mangner T.J. et al. Synthesis of 2′-deoxy-2′-[18F]fluoro-beta-D-arabinofuranosyl nucleosides, [18F]FAU, [18F]FMAU, [18F]FBAU, [18F]FIAU, as potential PET agents for imaging cellular proliferation. Nucl. Med. Biol. 2003, 30, 215-224.
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2. Buursma A.R. et al. 18F-FEAU as a radiotracer for herpes simplex virus thymidine kinase gene expression: in-vitro comparison with other PET tracers. Nucl. Med. Commun. 2006, 27, 25-30.
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3. Alauddin M.M. et al. Direct comparison of radiolabeled probes FMAU, FHBG, and FHPG as PET imaging agents for HSV1-tk expression in a human breast cancer model. Mol. Imaging 2004, 3, 76-84.
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4. Alauddin M.M. et al. Synthesis and evaluation of 2′-deoxy-2′-18F-fluoro-5-fluoro-1-beta-D-arabinofuranosyluracil as a potential PET imaging agent for suicide gene expression. J. Nucl. Med. 2004, 45, 2063-2069
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date of product catalogue issue:
05 April 2012
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